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产品信息
PA5-20818
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid peptide from near the amino terminus of human SKA2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152887
产品详细信息
A suggested positive control is NIH-3T3 cell lysate.
PA5-20818 can be used with blocking peptide PEP-0932.
靶标信息
Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: family with sequence similarity 33, member A; Protein FAM33A; SKA complex subunit 2; Spindle and kinetochore-associated protein 2; spindle and KT (kinetochore) associated 2
基因别名: 1110001A07Rik; C78640; FAM33A; SKA2
UniProt ID: (Human) Q8WVK7, (Mouse) Q9CR46
Entrez Gene ID: (Human) 348235, (Mouse) 66140
