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产品信息
MA5-35746
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1384
抗原
A synthetic peptide corresponding to a sequence within amino acids 64-163 of human SKP1 (P63208)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849646
产品详细信息
Immunogen sequence: HHKDDPPPPE DDENKEKRTD DIPVWDQEFL KVDQGTLFEL ILAANYLDIK GLLDVTCKTV ANMIKGKTPE EIRKTFNIKN DFTEEEEAQV RKENQWCEEK
靶标信息
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteasome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; Cyclin-A/CDK2-associated protein p19; MGC34403; OCP-2; OCP-II; OCP-II protein; Organ of Corti protein 2; Organ of Corti protein II; p19A; p19skp1; polypeptide 1-like; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; S-phase kinase-associated protein 1A; SIII; Transcription elongation factor B polypeptide 1-like
基因别名: 15kDa; 2610043E24Rik; 2610206H23Rik; EMC19; OCP-II; OCP2; p19A; p19Skp1; SKP1; SKP1A; TCEB1L
UniProt ID: (Human) P63208, (Rat) Q6PEC4, (Mouse) Q9WTX5
Entrez Gene ID: (Human) 6500, (Rat) 287280, (Mouse) 21402
G2/M transition of mitotic cell cycle
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
Wnt signaling pathway
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
histone H2A monoubiquitination
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
T cell receptor signaling pathway
stress-activated MAPK cascade
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
ubiquitin-dependent protein catabolic process
