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SLC11A1/NRAMP1 (extracellular) Antibody (ANT-201-200UL) in IHC (F)
Expression of NRAMP1 in rat hippocampus. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-SLC11A1/NRAMP1 (extracellular) Antibody (#ANT-201), (1:600), followed by goat Anti-rabbit-Alexa-488. A. Staining in the dentate gyrus region showed NRAMP1 immunoreactivity (green) in the granule layer (G) and in hilar interneurons (arrows). B. Pre-incubation of the Antibody with SLC11... View More
产品信息
ANT-201-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CANSSLHDYAKIFP(R), corresponding to amino acid residues 322-335 of human SLC11A1, 4th extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: host resistance locus Bcg/Ity/Lsh; natural resistance associated macrophage protein 1; Natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; solute carrier family 11 (sodium/phosphate symporters), member 1; Solute carrier family 11 member 1
基因别名: Bcg; Itg; Ity; LSH; NRAMP; NRAMP1; SLC11A1
UniProt ID: (Human) P49279, (Mouse) P41251, (Rat) P70553
Entrez Gene ID: (Human) 6556, (Mouse) 18173, (Rat) 316519
protein import into nucleus, translocation
negative regulation of cytokine production
positive regulation of cytokine production
T cell proliferation involved in immune response
T cell cytokine production
positive regulation of dendritic cell antigen processing and presentation
positive regulation of T-helper 1 type immune response
iron ion transport
manganese ion transport
cellular cadmium ion homeostasis
cellular iron ion homeostasis
phagocytosis
inflammatory response
vacuolar acidification
response to bacterium
positive regulation of gene expression
nitrite transport
activation of protein kinase activity
response to lipopolysaccharide
interleukin-2 production
interleukin-3 production
positive regulation of interferon-gamma production
response to interferon-gamma
wound healing
macrophage activation
defense response to bacterium
defense response to protozoan
L-arginine import
MHC class II biosynthetic process
cell redox homeostasis
respiratory burst
positive regulation of transcription from RNA polymerase II promoter
antigen processing and presentation of peptide antigen
mRNA stabilization
positive regulation of phagocytosis
defense response to Gram-negative bacterium
iron ion homeostasis
multicellular organismal iron ion homeostasis
cadmium ion transmembrane transport
divalent metal ion export
manganese ion transmembrane transport
MAPK cascade
transport
ion transport
hydrogen ion transmembrane transport
biological_process
