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SLC16A2 Antibody (PA5-101676) in IHC (P)
Immunohistochemistry analysis of SLC16A2 in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SLC16A2 polyclonal antibody (Product # PA5-101676) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-101676
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SLC16A2(Accession P36021), corresponding to amino acid residues N111-V161.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851110
产品详细信息
Antibody detects endogenous levels of total SLC16A2.
靶标信息
Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiency (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MCT 7; MCT 8; monocarboxylate transporter; Monocarboxylate transporter 7; Monocarboxylate transporter 8; Monocarboxylate transporter 8 (MCT 8) (X-linked PEST-containing transporter); solute carrier family 16 (monocarboxylic acid transporters), member 2; Solute carrier family 16 member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter); X-linked PEST-containing transporter
基因别名: AHDS; AW105741; DXS128; DXS128E; MCT 7; MCT 8; MCT7; MCT8; MRX22; SLC16A2; XPCT
UniProt ID: (Human) P36021, (Rat) Q8K1P8, (Mouse) O70324
Entrez Gene ID: (Human) 6567, (Rat) 259248, (Mouse) 20502
