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PA1-9553 detects SLC19A1 in human samples.
PA1-9553 has been successfully used in Western blot procedures. By Western blot, PA1-9553 detects a 65 kDa protein representing SLC19A1.
PA1-9553 immunogen is a purified recombinant SLC19A1 corresponding to the chromosome 21 gene (Human).
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cyclic dinucleotide:anion antiporter SLC19A1; Folate:anion antiporter SLC19A1; FOLT; hSLC19A1; IFC-1; Intestinal folate carrier 1; Placental folate transporter; Reduced folate carrier protein; Reduced folate transporter; Reduced folate transporter 1; RFC; RFT-1; solute carrier family 19 (folate transporter), member 1; Solute carrier family 19 member 1
基因别名: CHMD; FLOT1; FOLT; IFC1; REFC; RFC1; SLC19A1
UniProt ID: (Human) P41440
Entrez Gene ID: (Human) 6573
分子生物学功能:
transporter