Invitrogen

SLC22A1 Monoclonal Antibody (2C5)

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SLC22A1 Antibody (MA5-15730) in WB

Western blot analysis of SLC22A1 using SLC22A1 monoclonal antibody (Product # MA5-15730) in HEK293 (1) and SLC22A1 (AA: 284-347) human IgG Fc transfected HEK293 (2) cell lysate.

SLC22A1 Antibody in Flow Cytometry (Flow)

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产品信息

MA5-15730

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看3篇已发表文章 3篇已发表文章

流式细胞分析 (Flow)

1:200-1:400

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

2C5

抗原

Purified recombinant fragment of human SLC22A1 expressed in E. Coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

ascites

内含物

0.03% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_10983915

产品详细信息

MA5-15730 targets SLC22A1 in indirect ELISA, FACS and WB applications and shows reactivity with Human samples.

The MA5-15730 immunogen is purified recombinant fragment of human SLC22A1 expressed in E. Coli.

MA5-15730 detects SLC22A1 which has a predicted molecular weight of approximately 61.2kDa.

靶标信息

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Divergent Regulation of OCT and MATE Drug Transporters by Cadmium Exposure.

Pharmaceutics

Yang H,Zhou S,Guo D,Obianom ON,Li Q,Shu Y

Published figure using SLC22A1 monoclonal antibody (Product # MA5-15730) in Western Blot

Tue Apr 13 00:00:00 EDT 2021

A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells.

PloS one

Chow JPH,Cai Y,Chow DTL,Chung SHK,Chau KC,Ng KY,Leung OM,Wong RMH,Law AWL,Leung YO,Kwok SY,Leung YC

MA5-15730 was used in Western Blotting to explore the anti-cancer efficacy of NEI-01 treatment.

Tue Jul 14 00:00:00 EDT 2020

A modified arginine-depleting enzyme NEI-01 inhibits growth of pancreatic cancer cells.

PloS one

Chow JPH,Cai Y,Chow DTL,Chung SHK,Chau KC,Ng KY,Leung OM,Wong RMH,Law AWL,Leung YO,Kwok SY,Leung YC

MA5-15730 was used in Western Blotting to explore the anti-cancer efficacy of NEI-01 treatment.

Tue Jul 14 00:00:00 EDT 2020

Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2.

Molecular pharmaceutics

Obianom ON,Coutinho AL,Yang W,Yang H,Xue F,Shu Y

MA5-15730 was used in Western Blotting to demonstrate that inclusion of a biguanide functionality can potentiate uptake by the organic cation transporters 1 and 2 (OCT1 and OCT2).

Mon Aug 07 00:00:00 EDT 2017

生物信息学

蛋白别名: 1-Oct; DKFZp313N1010; FLJ25043; FLJ37489; H oct1_cds; hOCT1; Organic cation transporter 1; solute carrier family 22 (organic cation transporter), member 1; Solute carrier family 22 member 1; SYK

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基因别名: HOCT1; OCT1; oct1_cds; SLC22A1

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UniProt ID: (Human) O15245

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Entrez Gene ID: (Human) 6580

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功能

acetylcholine transmembrane transporter activity dopamine transmembrane transporter activity norepinephrine transmembrane transporter activity protein binding secondary active organic cation transmembrane transporter activity organic cation transmembrane transporter activity quaternary ammonium group transmembrane transporter activity protein homodimerization activity secondary carrier transporter

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