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SLC22A4 Antibody (PA5-87939) in WB
Western blot analysis of SLC22A4 in extracts of various cell lines. Samples were incubated with SLC22A4 Polyclonal antibody (Product # PA5-87939) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-87939
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 42-141 of human SLC22A4 (NP_0030502)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804522
产品详细信息
Immunogen sequence: LAGTPEHRCR VPDAANLSSA WRNNSVPLRL RDGREVPHSC SRYRLATIAN FSALGLEPGR DVDLGQLEQE SCLDGWEFSQ DVYLSTVVTE WNLVCEDNWK; Positive Samples: SW480, HL-60, NCI-H460, LO2, HeLa, Mouse kidney, Mouse liver, Rat liver; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
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生物信息学
蛋白别名: Ergothioneine transporter; ET transporter; integral membrane transport protein; LSTP-Like 2; OCTN1; organic cation transporter 1; organic cation transporter OCTN1; Organic cation/carnitine transporter 1; solute carrier family (organic cation transporter), member 4; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; Solute carrier family 22 member 4
基因别名: ETT; OCTN1; SLC22A4; UT2H
UniProt ID: (Human) Q9H015, (Rat) Q9R141, (Mouse) Q9Z306
Entrez Gene ID: (Human) 6583, (Rat) 64037, (Mouse) 30805
nucleotide binding
protein binding
ATP binding
secondary active organic cation transmembrane transporter activity
carnitine transmembrane transporter activity
symporter activity
cation:cation antiporter activity
quaternary ammonium group transmembrane transporter activity
PDZ domain binding
organic cation transmembrane transporter activity
transporter activity
ion transmembrane transporter activity
transmembrane transporter activity
secondary carrier transporter
triglyceride metabolic process
sodium ion transport
body fluid secretion
carnitine metabolic process
organic cation transport
quaternary ammonium group transport
carnitine transport
cation transmembrane transport
carnitine transmembrane transport
amino acid transmembrane transport
ion transmembrane transport
modified amino acid transport
transport
ion transport
transmembrane transport
