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SLC25A13 Antibody (PA5-103678) in ICC/IF
Immunofluorescent analysis of SLC25A13 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and SLC25A13 polyclonal antibody (Product # PA5-103678) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-103678
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SLC25A13(Accession Q9UJS0), corresponding to amino acid residues L603-K653.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853012
产品详细信息
Antibody detects endogenous levels of total SLC25A13.
靶标信息
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARALAR-related gene 2; Calcium-binding mitochondrial carrier protein Aralar2; Citrin; Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial; Mitochondrial aspartate glutamate carrier 2; solute carrier family 25 (aspartate/glutamate carrier), member 13; Solute carrier family 25 member 13; solute carrier family 25, member 13
基因别名: AI785475; ARALAR2; CITRIN; CTLN2; Ctrn; SLC25A13
UniProt ID: (Human) Q9UJS0, (Mouse) Q9QXX4
Entrez Gene ID: (Human) 10165, (Mouse) 50799
structural constituent of ribosome
transporter activity
L-glutamate transmembrane transporter activity
calcium ion binding
acidic amino acid transmembrane transporter activity
L-aspartate transmembrane transporter activity
metal ion binding
calcium-binding protein
calmodulin-related
transporter
secondary carrier transporter
