Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 5
SLC26A3 Antibody (PA5-68530) in IHC (P)
Immunohistochemical analysis of SLC26A3 in paraffin-embedded human adult liver tissue. Sample was probed with a SLC26A3 polyclonal antibody (Product # PA5-68530) at a dilution of 1:600. Detection was performed with a donkey anti-Rabbit Cy2/3 secondary antibody at a dilution of 1:200. Images were taken at 20x magnification with an exposure time of 0.5-2.0 seconds.
产品信息
PA5-68530
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human SLC26A3
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2688605
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 79%; Guinea Pig: 79%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 86%; Rat: 93%; Sheep: 100%
靶标信息
SLC26A3 is a chloride/bicarbonate exchanger that is involved in absorption inside the colon. SLC26A3 helps mediate electrolyte and fluid absorption. The protein encoded by the SLC26A3 gene is a transmembrane glycoprotein that functions as a sulfate transporter, and it is localized to the mucosa. The chloride ions transported by SLC26A3 cross the cell membrane in exchange for biocarbonate ions. SLC26A3 is localized in the mucosa of the lower intestinal tract, specifically the apical membrane of the columnar epithelium and in some goblet cells. Diseases associated with SLC26A3 protein dysfunction include congenital chloride diarrhea and congenital secretory chloride diarrhea 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Chloride anion exchanger; Down-regulated in adenoma; down-regulated in adenoma protein; Protein DRA; solute carrier family 26 (anion exchanger), member 3; Solute carrier family 26 member 3; solute carrier family 26, member 3
基因别名: CLD; DRA; SLC26A3
UniProt ID: (Human) P40879
Entrez Gene ID: (Human) 1811
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
transporter activity
chloride channel activity
inorganic anion exchanger activity
protein binding
secondary active sulfate transmembrane transporter activity
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
sulfate transmembrane transporter activity
anion:anion antiporter activity
oxalate transmembrane transporter activity
transporter
regulation of transcription, DNA-templated
ion transport
anion transport
excretion
bicarbonate transport
oxalate transport
regulation of membrane potential
sperm capacitation
regulation of intracellular pH
intracellular pH elevation
membrane hyperpolarization
cellular response to cAMP
sulfate transmembrane transport
chloride transmembrane transport
