Osenses

SLC26A5 Polyclonal Antibody

产品信息

OSS00288W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200-1:2,000

免疫组化 (IHC)

1:200-1:2,000

其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from n-terminal region of human Prestin (SLC26A5, PRES) conjugated to an immunogenic carrier protein was used as the antigen

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: SLC26A5.

靶标信息

SLC26A5 is a member of the SLC26A/SulP transporter family. SLC26A5 is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in its gene have been associated with non-syndromic hearing loss.This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The DNA sequence of human chromosome 7.

Nature

Hillier LW,Fulton RS,Fulton LA,Graves TA,Pepin KH,Wagner-McPherson C,Layman D,Maas J,Jaeger S,Walker R,Wylie K,Sekhon M,Becker MC,O'Laughlin MD,Schaller ME,Fewell GA,Delehaunty KD,Miner TL,Nash WE,Cordes M,Du H,Sun H,Edwards J,Bradshaw-Cordum H,Ali J,Andrews S,Isak A,Vanbrunt A,Nguyen C,Du F,Lamar B,Courtney L,Kalicki J,Ozersky P,Bielicki L,Scott K,Holmes A,Harkins R,Harris A,Strong CM,Hou S,Tomlinson C,Dauphin-Kohlberg S,Kozlowicz-Reilly A,Leonard S,Rohlfing T,Rock SM,Tin-Wollam AM,Abbott A,Minx P,Maupin R,Strowmatt C,Latreille P,Miller N,Johnson D,Murray J,Woessner JP,Wendl MC,Yang SP,Schultz BR,Wallis JW,Spieth J,Bieri TA,Nelson JO,Berkowicz N,Wohldmann PE,Cook LL,Hickenbotham MT,Eldred J,Williams D,Bedell JA,Mardis ER,Clifton SW,Chissoe SL,Marra MA,Raymond C,Haugen E,Gillett W,Zhou Y,James R,Phelps K,Iadanoto S,Bubb K,Simms E,Levy R,Clendenning J,Kaul R,Kent WJ,Furey TS,Baertsch RA,Brent MR,Keibler E,Flicek P,Bork P,Suyama M,Bailey JA,Portnoy ME,Torrents D,Chinwalla AT,Gish WR,Eddy SR,McPherson JD,Olson MV,Eichler EE,Green ED,Waterston RH,Wilson RK

Thu Jul 10 00:00:00 EDT 2003

Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss.

Human molecular genetics

Liu XZ,Ouyang XM,Xia XJ,Zheng J,Pandya A,Li F,Du LL,Welch KO,Petit C,Smith RJ,Webb BT,Yan D,Arnos KS,Corey D,Dallos P,Nance WE,Chen ZY

Thu May 15 00:00:00 EDT 2003

生物信息学

蛋白别名: MGC118886; MGC118887; MGC118888; MGC118889; Prestin; prestin (motor protein); solute carrier family 26 (anion exchanger), member 5; Solute carrier family 26 member 5

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基因别名: DFNB61; PRES; SLC26A5

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UniProt ID: (Human) P58743

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Entrez Gene ID: (Human) 375611

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功能

chloride channel activity transcription factor binding secondary active sulfate transmembrane transporter activity bicarbonate transmembrane transporter activity sulfate transmembrane transporter activity anion:anion antiporter activity oxalate transmembrane transporter activity spectrin binding protein homodimerization activity transporter

参与通路