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SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Amino acid transporter A3; amino acid transporter system A3; FLJ10191; MGC126876; N amino acid transporter 3; Na(+)-coupled neutral amino acid transporter 4; Sodium-coupled neutral amino acid transporter 4; Solute carrier family 38 member 4; solute carrier family 38, member 4; System A amino acid transporter 3; System N amino acid transporter 3; system-N amino acid transporter 3
基因别名: 1110012E16Rik; 1700012A18Rik; ATA3; mATA3; mNAT3; NAT3; PAAT; SLC38A4; SNAT4
UniProt ID: (Human) Q969I6, (Mouse) Q8R1S9
Entrez Gene ID: (Human) 55089, (Mouse) 69354
分子生物学功能:
amino acid transporter