Invitrogen

SLC6A4 Recombinant Rabbit Monoclonal Antibody (16H2L7)

SLC6A4 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

SLC6A4 Antibody (702076) in ICC/IF

For immunofluorescence analysis, IMR-32 cells were fixed and permeabilized for detection of endogenous SERT using Anti- SERT Recombinant Rabbit Monoclonal Antibody (Product # 702076, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of SERT protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S3693... View More

Product Image Gallery

产品信息

702076

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

免疫细胞化学 (ICC/IF)

1-2 µg/mL

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

16H2L7

抗原

Peptides corresponding to Human SLC6A4 (aa 444-462, 16-29)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2633059

产品详细信息

This antibody is predicted to react with Monkey, Horse and Cat

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neurons.

Translational psychiatry

Elsworthy RJ,Crowe JA,King MC,Dunleavy C,Fisher E,Ludlam A,Parri HR,Hill EJ,Aldred S

Published figure using SLC6A4 recombinant monoclonal antibody (Product # 702076) in Immunocytochemistry

Mon Jul 18 00:00:00 EDT 2022

生物信息学

蛋白别名: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; Na+/Cl- dependent serotonin transporter; OTTHUMP00000163633; serotonin transporter; serotonin transporter 1; SERT; Sodium-dependent serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 member 4; solute carrier family 6, member 4

查看更多收起

基因别名: 5-HTT; 5-HTTLPR; 5HTT; AI323329; hSERT; HTT; OCD1; SERT; SERT1; SLC6A4

查看更多收起

UniProt ID: (Human) P31645, (Rat) P31652, (Mouse) Q60857

查看更多收起

Entrez Gene ID: (Human) 6532, (Rat) 25553, (Mouse) 15567

查看更多收起

功能