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SMAD6 Antibody (PA5-99401) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded SMAD6 in human lung tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with SMAD6 polyclonal antibody (Product # PA5-99401) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-99401
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SMAD6(Accession O43541), corresponding to amino acid residues Q352-A402.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818334
产品详细信息
Antibody detects endogenous levels of total SMAD6.
靶标信息
SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAD homolog 6; Mad homolog 7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; mothers against DPP homolog 6; SMAD; SMAD 6; SMAD family member 6; SMAD SMAD; SMAD, mothers against DPP homolog 6
基因别名: AOVD2; b2b390Clo; HsT17432; MADH6; MADH7; Msmad6; SMAD6
UniProt ID: (Human) O43541, (Mouse) O35182
Entrez Gene ID: (Human) 4091, (Mouse) 17130
RNA polymerase II core promoter proximal region sequence-specific DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
ubiquitin protein ligase binding
type I transforming growth factor beta receptor binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding
co-SMAD binding
I-SMAD binding
R-SMAD binding
type I activin receptor binding
DNA binding
DNA-binding transcription factor
gene-specific transcriptional regulator
ureteric bud development
outflow tract septum morphogenesis
mitral valve morphogenesis
pulmonary valve morphogenesis
ventricular septum development
transcription, DNA-templated
immune response
transforming growth factor beta receptor signaling pathway
zygotic specification of dorsal/ventral axis
negative regulation of cell proliferation
negative regulation of SMAD protein complex assembly
negative regulation of ossification
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
cell-substrate adhesion
response to laminar fluid shear stress
aorta development
negative regulation of apoptotic process
response to estrogen
fat cell differentiation
negative regulation of pathway-restricted SMAD protein phosphorylation
coronary vasculature development
regulation of transcription, DNA-templated
intracellular signal transduction
positive regulation of vasoconstriction
negative regulation of vasodilation
cardiac vascular smooth muscle cell development
coronary vasculature morphogenesis
