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Proteintech

SMARCA4/BRG1 Polyclonal Antibody

42 篇参考文献
查看其他31个BRG1抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

21634-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:4,000
查看18篇已发表文章 18篇已发表文章

免疫组化 (IHC)

-
查看9篇已发表文章 9篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

1:10-1:100
查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
查看3篇已发表文章 3篇已发表文章

染色质免疫沉淀 实验 (ChIP)

-
查看6篇已发表文章 6篇已发表文章

RNA免疫共沉淀 (RIP)

-
查看2篇已发表文章 2篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Bovine, Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SMARCA4/BRG1 Fusion Protein Ag16256 (207-298 aa encoded by BC150298)
查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.65 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: KRPMPGMQQ QMPTLPPPSV SATGPGPGPG PGPGPGPGPA PPNYSRPHGM GGPNMPPPGP SGVPPGMPGQ PPGGPPKPWP EGPMANAAAP TST (207-298 aa encoded by BC150298)

靶标信息

Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1

基因别名: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; brg-1; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; RTPS2; SMARCA4; SNF2; SNF2B; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2

UniProt ID: (Human) P51532, (Mouse) Q3TKT4

Entrez Gene ID: (Human) 6597, (Mouse) 20586, (Rat) 171379

功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription coactivator activity RNA polymerase I CORE element sequence-specific DNA binding p53 binding transcription coactivator activity transcription corepressor activity helicase activity protein binding ATP binding DNA-dependent ATPase activity transcription factor binding Tat protein binding nucleosomal DNA binding protein N-terminus binding androgen receptor binding DNA polymerase binding lysine-acetylated histone binding nucleotide binding RNA polymerase II regulatory region sequence-specific DNA binding DNA binding chromatin binding hydrolase activity hydrolase activity, acting on acid anhydrides hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ATPase activity protein complex binding histone binding DNA helicase
参与通路
negative regulation of transcription from RNA polymerase II promoter neural retina development nucleosome disassembly chromatin remodeling transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter during mitosis spermatid development nervous system development covalent chromatin modification positive regulation of Wnt signaling pathway negative regulation of cell growth ATP-dependent chromatin remodeling positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of androgen receptor signaling pathway positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter positive regulation of glucose mediated signaling pathway positive regulation of pri-miRNA transcription from RNA polymerase II promoter beta-catenin-TCF complex assembly negative regulation of G1/S transition of mitotic cell cycle cell morphogenesis blood vessel development vasculogenesis in utero embryonic development blastocyst growth blastocyst hatching liver development outflow tract morphogenesis nucleosome assembly methylation-dependent chromatin silencing regulation of transcription, DNA-templated transcription from RNA polymerase II promoter glial cell fate determination heart development positive regulation of cell proliferation DNA methylation on cytosine within a CG sequence chromatin modification stem cell population maintenance neurogenesis extracellular matrix organization keratinocyte differentiation regulation of cell migration forebrain development hindbrain development embryonic hindlimb morphogenesis aortic smooth muscle cell differentiation negative regulation of apoptotic process positive regulation of DNA binding histone H3 acetylation positive regulation of cell differentiation embryonic organ morphogenesis epidermis morphogenesis definitive erythrocyte differentiation heart trabecula formation pharyngeal arch artery morphogenesis lens fiber cell development
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