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产品信息
MA5-44231
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BL-205-2G8
抗原
Synthetic peptide representing a region between residue 1200 and the C-terminus (residue 1233) of human structural maintenance of chromosomes 1.
偶联物
形式
Liquid
浓度
50 µg/mL
纯化类型
purified
保存液
BBS, pH 7.8-8.6, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Wet ice
RRID
AB_2926361
产品详细信息
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
靶标信息
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromo proteins are conserved in eukaryotes and lead to mitotic chromosome segregatior defects. This suggests a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. Mutations in the gene can lead to Cornelia de Lange syndrome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686L19178; MGC138332; mitosis-specific chromosome segregation protein like protein beta; RP6-29D12.1; Sb1.8; segregation of mitotic chromosomes 1; SM1A; SMC protein 1A; SMC protein 1B; SMC-1-alpha; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1alpha protein; Structural maintenance of chromosomes protein 1A; Structural maintenance of chromosomes protein 1B
基因别名: CDLS2; DXS423E; KIAA0178; SB1.8; SMC1; SMC1A; SMC1alpha; SMC1B; SMC1BETA; SMC1L1; SMC1L2; SMCB
UniProt ID: (Human) Q14683, (Human) Q8NDV3
Entrez Gene ID: (Human) 8243, (Human) 27127
mitotic sister chromatid segregation
DNA repair
mitotic spindle organization
sister chromatid cohesion
mitotic sister chromatid cohesion
mitotic cell cycle checkpoint
meiotic nuclear division
response to radiation
protein sumoylation
stem cell population maintenance
negative regulation of DNA endoreduplication
signal transduction in response to DNA damage
cell division
