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SMG6 Antibody (PA5-115202) in ICC/IF
Immunocytochemistry analysis of SMG6 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115202). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-115202
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SMG6(Accession Q86US8), corresponding to amino acid residues P24-F74.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2899838
产品详细信息
Antibody detects endogenous levels of total EST1A.
靶标信息
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EST1 telomerase component homolog A; EST1-like protein A; Ever shorter telomeres 1A; hEST1A; hSmg5/7a; Nonsense mediated mRNA decay factor SMG6; Smg-6 homolog; Smg-6 homolog, nonsense mediated mRNA decay factor; SMG6 nonsense mediated mRNA decay factor; telomerase subunit EST1A; Telomerase-binding protein EST1A
基因别名: AI317223; AU041178; C17orf31; EST1A; hSMG5/7a; KIAA0732; LRRGT00040; RGD1309609; SMG-6; SMG6
UniProt ID: (Human) Q86US8, (Mouse) P61406
Entrez Gene ID: (Human) 23293, (Mouse) 103677, (Rat) 287522
endoribonuclease activity
protein binding
telomeric DNA binding
ribonucleoprotein complex binding
metal ion binding
telomerase RNA binding
DNA polymerase binding
DNA binding
nuclease activity
endonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
RNA metabolism protein
