Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
10825-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Goat,
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SNAP23 Fusion Protein Ag1269 (1-211 aa encoded by BC000148)
偶联物
Unconjugated
形式
Liquid
浓度
0.57 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDNLSSEEI QQRAHQITDE SLESTRRILG LAIESQDAGI KTITMLDEQK EQLNRIEEGL DQINKDMRET EKTLTELNKC CGLCVCPCNR TKNFESGKAY KTTWGDGGEN SPCNVVSKQP GPVTNGQLQQ PTTGAASGGY IKRITNDARE DEMEENLTQV GSILGNLKDM ALNIGNEIDA QNPQIKRITD KADTNRDRID IANARAKKLI DS (1-211 aa encoded by BC000148)
靶标信息
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: OTTHUMP00000161263; SNAP-23; Synaptosomal-associated protein 23; synaptosomal-associated protein 23 kD; synaptosomal-associated protein, 23 kD; synaptosomal-associated protein, 23kD; synaptosomal-associated protein, 23kDa; synaptosome associated protein 23kDa; Syndet; Vesicle-membrane fusion protein SNAP-23
基因别名: 23kDa; AA408749; HsT17016; SNAP-23; SNAP23; SNAP23A; SNAP23B; Sndt; Syndet
UniProt ID: (Human) O00161, (Mouse) O09044, (Rat) O70377
Entrez Gene ID: (Human) 8773, (Mouse) 20619, (Rat) 64630
histamine secretion by mast cell
post-Golgi vesicle-mediated transport
vesicle targeting
protein transport
synaptic vesicle priming
synaptic vesicle fusion to presynaptic active zone membrane
membrane fusion
protein complex assembly
transport
exocytosis
vesicle-mediated transport
regulation of exocytosis
