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产品信息
SOCS1-FITC
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 170-212 on human Suppressor of Cytokine signaling 1 protein.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; JAK2-binding protein; SOCS-1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP-3
基因别名: CIS1; CISH1; Cish7; JAB; SOCS-1; SOCS1; SSI-1; SSI1; TIP3
UniProt ID: (Human) O15524, (Mouse) O35716
Entrez Gene ID: (Human) 8651, (Mouse) 12703, (Rat) 252971
regulation of protein phosphorylation
negative regulation of protein kinase activity
JAK-STAT cascade
regulation of activation of JAK2 kinase activity
protein ubiquitination
cytokine-mediated signaling pathway
organ regeneration
response to estradiol
response to lipopolysaccharide
response to progesterone
regulation of growth
response to drug
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat3 protein
response to peptide hormone
fat cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
regulation of cytokine secretion
regulation of interferon-gamma-mediated signaling pathway
cellular response to amino acid stimulus
negative regulation of signal transduction
intracellular signal transduction
regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of catalytic activity
regulation of JAK-STAT cascade
response to cytokine
