Proteintech

SOCS3 Monoclonal Antibody (1G2B12)

SOCS3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SOCS3 Antibody (66797-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66797-1-Ig (SOCS3 antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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产品信息

66797-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:3,000

查看11篇已发表文章 11篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:500

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

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产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1G2B12

抗原

SOCS3 Fusion Protein Ag5386

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1000 µg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Aliquoting is unnecessary for -20°C storage.

靶标信息

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CIS-3; cytokine inducible SH2-containing protein 3; Cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; MGC71791; Protein EF-10; SOCS-3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3

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基因别名: ATOD4; CIS3; Cish3; EF-10; Ef10; SOCS-3; SOCS3; SSI-3; SSI3

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UniProt ID: (Human) O14543, (Mouse) O35718

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Entrez Gene ID: (Human) 9021, (Mouse) 12702

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功能

protein kinase inhibitor activity protein binding kinase modulator

参与通路