Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
SOD2 Antibody (CL55566474100UL) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite 555 Anti-Human SOD2 (Product # CL55566474100UL), Clone:3A6C2) (red), or 0.4 µg Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
产品信息
CL55566474100UL
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
3A6C2
偶联物
激发/发射光谱
555/570 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
靶标信息
Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: indophenoloxidase B; IPO B; manganese SOD; manganese superoxide dismutase; manganese-containing superoxide dismutase; mangano-superoxide dismutase; mitochondrial superoxide dismutase 2; Mn superoxide dismutase; Superoxide dimutase 2, mitochondrial; superoxide dismutase; superoxide dismutase (Mn type); superoxide dismutase 2, mitochondrial; Superoxide dismutase [Mn], mitochondrial
基因别名: IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6; Sod-2; SOD2
UniProt ID: (Human) P04179, (Rat) P07895, (Mouse) P09671
Entrez Gene ID: (Human) 6648, (Pig) 100154319, (Rat) 24787, (Mouse) 20656
response to reactive oxygen species
response to superoxide
age-dependent response to reactive oxygen species
release of cytochrome c from mitochondria
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
regulation of transcription from RNA polymerase II promoter
superoxide metabolic process
regulation of blood pressure
negative regulation of cell proliferation
removal of superoxide radicals
oxygen homeostasis
negative regulation of neuron apoptotic process
protein homotetramerization
oxidation-reduction process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
age-dependent response to oxidative stress
response to hypoxia
liver development
detection of oxygen
glutathione metabolic process
response to oxidative stress
mitochondrion organization
heart development
aging
sensory perception of sound
locomotory behavior
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
apoptotic mitochondrial changes
response to radiation
response to cold
post-embryonic development
response to manganese ion
response to zinc ion
response to selenium ion
response to gamma radiation
response to activity
respiratory electron transport chain
hemopoiesis
response to nutrient levels
response to lipopolysaccharide
response to L-ascorbic acid
response to silicon dioxide
response to isolation stress
response to immobilization stress
vasodilation
response to drug
response to hydrogen peroxide
superoxide anion generation
hydrogen peroxide metabolic process
negative regulation of apoptotic process
positive regulation of nitric oxide biosynthetic process
negative regulation of fat cell differentiation
response to cadmium ion
negative regulation of fibroblast proliferation
neuron development
response to axon injury
erythrophore differentiation
hydrogen peroxide biosynthetic process
regulation of catalytic activity
protein homooligomerization
response to electrical stimulus
regulation of mitochondrial membrane potential
iron ion homeostasis
response to hyperoxia
response to magnetism
cellular response to ethanol
