Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
13913-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Arthropod
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SODD/BAG4 Fusion Protein Ag4905 (107-457 aa encoded by BC038505)
偶联物
形式
Liquid
浓度
0.51 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody detects 66-70 kDa full-length BAG4 protein and 45 kDa, 60 kDa C-terminal fragments.
Immunogen sequence: ARSRAPYPS TYPVRPELQG QSLNSYTNGA YGPTYPPGPG ANTASYSGAY YAPGYTQTSY STEVPSTYRS SGNSPTPVSR WIYPQQDCQT EAPPLRGQVP GYPPSQNPGM TLPHYPYGDG NRSVPQSGPT VRPQEDAWAS PGAYGMGGRY PWPSSAPSAP PGNLYMTEST SPWPSSGSPQ SPPSPPVQQP KDSSYPYSQS DQSMNRHNFP CSVHQYESSG TVNNDDSDLL DSQVQYSAEP QLYGNATSDH PNNQDQSSSL PEECVPSDES TPPSIKKIIH VLEKVQYLEQ EVEEFVGKKT DKAYWLLEEM LTKELLELDS VETGGQDSVR QARKEAVCKI QAILEKLEKK GL (107-457 aa encoded by BC038505)
靶标信息
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BAG family molecular chaperone regulator 4; BAG-4; BAG-family molecular chaperone regulator-4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; Silencer of death domains
基因别名: BAG-4; BAG4; SODD
UniProt ID: (Human) O95429
Entrez Gene ID: (Human) 9530
protein folding
positive regulation of fibroblast migration
positive regulation of actin filament polymerization
positive regulation of peptidyl-serine phosphorylation
tumor necrosis factor-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of cell adhesion
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
protein localization to plasma membrane
ruffle assembly
regulation of cellular response to heat
negative regulation of protein targeting to mitochondrion
negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
