Bethyl Laboratories

SOS1 Polyclonal Antibody

查看其他11个SOS1抗体

产品信息

A301-890A-T

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫沉淀 (IP)

Assay-dependent

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Between 1283 and 1333

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.0 to 8.0, with 0.1% BSA

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Mouse

靶标信息

Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: G GINGF; gingival fibromatosis; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; Son of sevenless homolog 1; SOS-1

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基因别名: GF1; GGF1; GINGF; HGF; NS4; SOS1

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UniProt ID: (Human) Q07889

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Entrez Gene ID: (Human) 6654

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DNA binding guanyl-nucleotide exchange factor activity Ras guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity GTPase activator activity protein binding SH3 domain binding protein heterodimerization activity guanyl-nucleotide exchange factor

参与通路

MAPK cascade B cell homeostasis hair follicle development cardiac atrium morphogenesis pericardium morphogenesis signal transduction epidermal growth factor receptor signaling pathway Ras protein signal transduction vitellogenesis axon guidance insulin receptor signaling pathway regulation of T cell differentiation in thymus regulation of Rho protein signal transduction multicellular organism growth Fc-epsilon receptor signaling pathway ERBB2 signaling pathway regulation of T cell proliferation positive regulation of apoptotic process positive regulation of GTPase activity positive regulation of epidermal growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway blood vessel morphogenesis leukocyte migration regulation of small GTPase mediated signal transduction positive regulation of small GTPase mediated signal transduction palate development eyelid development in camera-type eye heart trabecula morphogenesis midbrain morphogenesis regulation of pro-B cell differentiation