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Invitrogen
SOX10 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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SOX10 Antibody (PA5-84795)
Relative expression in different tissues in IHC: Detection of differential expression levels of SOX10 demonstrates antibody specificity. Immunohistochemical analysis of SOX10 using anti-SOX10 Polyclonal Antibody (Product #PA5-84795), shows significant staining of SOX10 in cerebral cortex and shows minimal or weak staining in pancreas tissues. The relative expression levels of SOX10 within each tissue is sh... View More
产品信息
PA5-84795
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2791945
产品详细信息
Immunogen sequence: PHYTDQPSTS QIAYTSLSLP HYGSAFPSIS RPQFDYSDHQ PSGPYYGHSG
靶标信息
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dominant megacolon, mouse, human homolog of; MGC15649; SRY; SRY (sex determining region Y)-box 10; SRY box 10; SRY-related HMG-box gene 10; Transcription factor SOX-10
基因别名: DOM; PCWH; SOX10; WS2E; WS4; WS4C
UniProt ID: (Human) P56693
Entrez Gene ID: (Human) 6663
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
transcription factor binding
identical protein binding
in utero embryonic development
neural crest cell migration
positive regulation of neuroblast proliferation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
peripheral nervous system development
anatomical structure morphogenesis
positive regulation of gliogenesis
melanocyte differentiation
lacrimal gland development
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
enteric nervous system development
digestive tract morphogenesis
developmental growth
oligodendrocyte differentiation
stem cell differentiation
morphogenesis of a branching epithelium
negative regulation of canonical Wnt signaling pathway
