Invitrogen

SOX4 Monoclonal Antibody (CL5634)

查看其他17个SOX4抗体

产品信息

MA5-31423

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:1,000-1:2,500

-

免疫细胞化学 (ICC/IF)

2-10 µg/mL

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

CL5634

抗原

Synthetic peptide corresponding to Human SOX4

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2787059

产品详细信息

Immunogen sequence: AGADPSDPLG LYEEEGAG

靶标信息

SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 SOX genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: ecotropic viral integration site 16; SRY (sex determining region Y)-box 4; SRY box 4; SRY-box containing gene 4; SRY-related HMG-box gene 4; Transcription factor SOX-4

查看更多收起

基因别名: AA682046; EVI16; Sox-4; SOX4

查看更多收起

UniProt ID: (Human) Q06945, (Mouse) Q06831

查看更多收起

Entrez Gene ID: (Human) 6659, (Rat) 364712, (Mouse) 20677

查看更多收起

transcription regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding nucleic acid binding transcription factor activity transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator activity transcription factor activity, sequence-specific DNA binding protein binding protein heterodimerization activity RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding HMG box transcription factor

参与通路

skeletal system development neural tube formation pro-B cell differentiation mitral valve morphogenesis cardiac ventricle formation cardiac right ventricle morphogenesis atrial septum primum morphogenesis noradrenergic neuron differentiation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest heart development positive regulation of cell proliferation negative regulation of cell proliferation glial cell proliferation spinal cord development spinal cord motor neuron differentiation glial cell development positive regulation of Wnt signaling pathway T cell differentiation endocrine pancreas development negative regulation of protein ubiquitination regulation of protein stability positive regulation of insulin secretion somatic stem cell population maintenance ascending aorta morphogenesis glucose homeostasis DNA damage response, detection of DNA damage positive regulation of apoptotic process positive regulation of translation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of protein export from nucleus sympathetic nervous system development protein stabilization canonical Wnt signaling pathway limb bud formation ventricular septum morphogenesis negative regulation of cell death neuroepithelial cell differentiation kidney morphogenesis cellular response to glucose stimulus positive regulation of canonical Wnt signaling pathway positive regulation of N-terminal peptidyl-lysine acetylation response to hypoxia transcription, DNA-templated