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产品信息
PA5-115976
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human STK39(Accession Q9UEW8), corresponding to amino acid residues D381-V431.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900610
产品详细信息
Antibody detects endogenous levels of total STK39.
靶标信息
STK39 (STLK3) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DCHT; DKFZp686K05124; kidney-specific SPAK; Pancreatic serine/threonine-protein kinase; proline-alanine-rich STE20-related kinase; PS/TK; PSTK1; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine kinase 39, STE20/SPS1 homolog; Serine/threonine-protein kinase 39; small intestine SPAK-like kinase; Ste-20 related kinase; Ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1 homolog; STE20/SPS1-related proline-alanine-rich protein kinase
基因别名: AW227544; AW556857; DCHT; PASK; RF005; Rnl5; SPAK; STK39
UniProt ID: (Human) Q9UEW8, (Mouse) Q9Z1W9, (Rat) O88506
Entrez Gene ID: (Human) 27347, (Mouse) 53416, (Rat) 54348
negative regulation of protein phosphorylation
protein phosphorylation
regulation of mitotic cell cycle
regulation of blood pressure
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
intracellular signal transduction
regulation of apoptotic process
positive regulation of potassium ion transport
regulation of inflammatory response
cellular hypotonic response
negative regulation of pancreatic juice secretion
negative regulation of potassium ion transmembrane transporter activity
negative regulation of potassium ion transmembrane transport
regulation of ion homeostasis
negative regulation of rubidium ion transport
negative regulation of rubidium ion transmembrane transporter activity
response to stress
