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产品信息
MA5-17179
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4G5
抗原
Purified recombinant fragment of human SPIB (amino acids: 200-252) expressed in E. Coli.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.03% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2538650
产品详细信息
MA5-17179 targets SPIB in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17179 immunogen is purified recombinant fragment of human SPIB (amino acids: 200-252) expressed in E. Coli.
MA5-17179 detects SPIB which has a predicted molecular weight of approximately 28.8kDa.
靶标信息
Spi-B is a transcription factor belonging to a subfamily of ETS transcription factors with a conserved ETS domain that mediates specific DNA binding. Spi-B may form homotypic interactions and is known to interact with IRF4, CREBBP, EP300, SPI1/PU.1 related, JUN and TBP. As a sequence specific transcriptional activator it binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Two isoforms of Spi-B are reported. Spi-B is usually expressed in plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells and promotes their development and block viral replication. Spi-B is not expressed in T-cells or granulocytes but may be present in stem cell populations of the liver and B-cells where it helps in B-cell receptor (BCR) signaling, normal B-cell development and antigenic stimulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ets transcription factor Spi-B; Spi-1/PU.1 related; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
基因别名: SPI-B; SPIB
UniProt ID: (Human) Q01892, (Mouse) O35906
Entrez Gene ID: (Human) 6689, (Mouse) 272382
