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产品信息
PA5-31130
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 50 and 274 of Human Serine palmitoyltransferase 2
偶联物
形式
Liquid
浓度
0.41 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548604
产品详细信息
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse liver.
Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (80%), Chicken (84%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LCB 2; LCB2a; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine palmitoyltransferase 2; serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2
基因别名: AI173915; hLCB2a; HSN1C; KIAA0526; LCB2; LCB2A; mKIAA0526; NSAN1C; SPT2; SPTLC2
UniProt ID: (Human) O15270, (Mouse) P97363
Entrez Gene ID: (Human) 9517, (Mouse) 20773
