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产品信息
TA502127
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
OTI1E9
抗原
Full length human recombinant protein of human SQSTM1 produced in HEK293T cell.
偶联物
形式
Liquid
浓度
0.86 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; oxidative stress induced; oxidative stress induced like; phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome-1; Ubiquitin-binding protein p62
基因别名: A170; FTDALS3; ORCA; Osi; OSIL; p60; p62; p62B; PDB3; SQSTM1; ZIP; ZIP3
UniProt ID: (Human) Q13501, (Rat) O08623
Entrez Gene ID: (Human) 8878, (Rat) 113894
protein serine/threonine kinase activity
protein kinase C binding
protein binding
zinc ion binding
protein kinase binding
receptor tyrosine kinase binding
ubiquitin protein ligase binding
SH2 domain binding
identical protein binding
protein homodimerization activity
ubiquitin binding
K63-linked polyubiquitin binding
positive regulation of protein phosphorylation
immune system process
ubiquitin-dependent protein catabolic process
autophagy
apoptotic process
macroautophagy
positive regulation of macroautophagy
cell differentiation
regulation of I-kappaB kinase/NF-kappaB signaling
protein heterooligomerization
regulation of mitophagy
mitophagy
protein phosphorylation
response to stress
protein localization
regulation of mitochondrion organization
endosomal transport
intracellular signal transduction
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of growth of symbiont in host
positive regulation of transcription from RNA polymerase II promoter
regulation of Ras protein signal transduction
regulation of protein complex stability
mitophagy in response to mitochondrial depolarization
