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产品信息
26001-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SRD5A1 Fusion Protein Ag23351 (1-163 aa encoded by BC007033)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MATATGVAE ERLLAALAYL QCAVGCAVFA RNRQTNSVYG RHALPSHRLR VPARAAWVVQ ELPSLALPLY QYASESAPRL RSAPNCILLA MFLVHYGHRC LIYPFLMRGG KPMPLLACTM AIMFCTCNGY LQSRYLSHCA VYADDWVTDP RFLIGFGLWL TGML (1-163 aa encoded by BC007033)
靶标信息
Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5alpha-Reductase 1 is expressed in all portions of the hair follicle, whereas 5alpha-Reductase 2 is expressed only in mesenchymal portions. In addition, 5alpha-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5alpha-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1; steroid 5-alpha-reductase type I; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); type 1 5alpha-reductase
基因别名: 0610031P22Rik; 4930435F02Rik; S5AR 1; Srd5a-1; SRD5A1
UniProt ID: (Human) P18405, (Mouse) Q68FF9
Entrez Gene ID: (Human) 6715, (Mouse) 78925
urogenital system development
liver development
steroid biosynthetic process
androgen biosynthetic process
sex determination
male gonad development
cellular response to starvation
response to muscle activity
diterpenoid metabolic process
spinal cord development
hippocampus development
thalamus development
hypothalamus development
pituitary gland development
cerebral cortex development
cell differentiation
male genitalia development
female genitalia development
response to follicle-stimulating hormone
cellular response to insulin stimulus
serotonin metabolic process
progesterone metabolic process
response to drug
circadian sleep/wake cycle, REM sleep
response to estrogen
oxidation-reduction process
bone development
response to growth hormone
response to fungicide
cellular response to cAMP
cellular response to growth factor stimulus
cellular response to estradiol stimulus
cellular response to testosterone stimulus
cellular response to dexamethasone stimulus
cellular response to epinephrine stimulus
lipid metabolic process
sex differentiation
steroid metabolic process
androgen metabolic process
