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产品信息
BS-1402R
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human SREBP-1.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADD1; adipocyte determination and differentiation-dependent factor 1; Adipocyte determination- and differentiation-dependent factor 1; bHLHd1; bHLHd2; Class D basic helix-loop-helix protein 1; Class D basic helix-loop-helix protein 2; srebf2; srebf2 {ECO:0000312|EMBL:AAI01903.1}; SREBP-1; SREBP-2; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding transcription factor 2; sterol response element binding protein 1
基因别名: ADD-1; ADD1; AI608257; BHLHD1; BHLHD2; D630008H06; lop13; nuc; SREBF1; SREBF2; Srebf2_retired; SREBP-1; SREBP-1a; SREBP-1c; SREBP-2; SREBP1; SREBP1a; SREBP1c; SREBP2; SREBP2gc
UniProt ID: (Human) P36956, (Human) Q12772, (Rat) P56720, (Mouse) Q9WTN3, (Rat) Q3T1I5, (Mouse) Q3U1N2
Entrez Gene ID: (Human) 6720, (Bovine) 539361, (Bovine) 507102, (Human) 6721, (Rat) 78968, (Mouse) 20787, (Rat) 300095, (Mouse) 20788
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein kinase binding
protein complex binding
sterol response element binding
protein dimerization activity
C-8 sterol isomerase activity
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein C-terminus binding
E-box binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
spermatogenesis
aging
cholesterol metabolic process
lipid biosynthetic process
response to hormone
response to lead ion
positive regulation of cholesterol storage
response to lipid
response to drug
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of cholesterol homeostasis
regulation of heart rate by chemical signal
regulation of transcription from RNA polymerase II promoter
lipid metabolic process
circadian rhythm
insulin receptor signaling pathway
cellular response to starvation
response to glucose
positive regulation of triglyceride biosynthetic process
regulation of fatty acid metabolic process
lung development
positive regulation of histone deacetylation
regulation of protein stability
response to food
response to retinoic acid
response to progesterone
response to glucagon
mRNA transcription from RNA polymerase II promoter
fat cell differentiation
positive regulation of cholesterol biosynthetic process
negative regulation of insulin secretion
response to cAMP
cellular response to fatty acid
regulation of mitophagy
regulation of protein targeting to mitochondrion
response to organic cyclic compound
response to insulin
cellular response to insulin stimulus
response to peptide hormone
regulation of insulin secretion
response to fatty acid
cellular response to laminar fluid shear stress
positive regulation of protein targeting to mitochondrion
transcription from RNA polymerase II promoter
steroid metabolic process
positive regulation of fatty acid biosynthetic process
