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Positive Samples: Mouse heart, Mouse liver
Immunogen sequence: EDDEVGYSHP RYKDTPWCSP IKVKYGDVYC RAPQGGYYKT ALGTRCDIRC QKGYELHGSS LLICQSNKRW SDKVICKQKR CPTLAMPANG GFKCVDGAYF NSRCEYYCSP GYTLKGERTV TCMDNKAWSG RPASCVDMEP PRIKCPSVKE RIAEPNKLTV RVSWETPEGR DTADGILTDV ILKGLPPGSN FPEGDHKIQY TVYDRAENKG TCKFRVKVRV KRCGKLNAPE NGYMKCSSDG DNYGATCEFS CIGGYELQGS PARVCQSNLA WSGTEPTCAA M
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DRS protein; Sushi-repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome
基因别名: drs; drs-1; drs-2; mDRS-1; mDRS-2; Srpx
UniProt ID: (Mouse) Q9R0M3
Entrez Gene ID: (Mouse) 51795