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SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cancer/testis antigen 5.2; cancer/testis antigen family 5, member 2a; CT5.2; MGC119055; MGC15364; MGC3884; Protein SSX2; sarcoma, synovial, X-chromosome-related 2; Synovial sarcoma, X breakpoint 2; synovial sarcoma, X breakpoint 2B; Tumor antigen HOM-MEL-40
基因别名: CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX; SSX2; SSX2A; SSX2B
UniProt ID: (Human) Q16385
Entrez Gene ID: (Human) 6757