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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
STAG3 is a meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cohesin subunit SA-3; MGC119262; MGC119264; MGC119265; NHLRC 1; SCC3 homolog 3; Stromal antigen 3; Stromalin 3; Stromalin-3
基因别名: STAG3
UniProt ID: (Human) Q9UJ98
Entrez Gene ID: (Human) 10734
分子生物学功能:
chromatin/chromatin-binding, or -regulatory protein