Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-95765
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 64-285 of human StAR (NP_0003402)
偶联物
形式
Liquid
浓度
2.56 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807567
产品详细信息
Positive Samples: K-562, Mouse ovary, Rat testis; Cellular Location: Mitochondrion
Immunogen sequence: EETLYSDQEL AYLQQGEEAM QKALGILSNQ EGWKKESQQD NGDKVMSKVV PDVGKVFRLE VVVDQPMERL YEELVERMEA MGEWNPNVKE IKVLQKIGKD TFITHELAAE AAGNLVGPRD FVSVRCAKRR GSTCVLAGMA TDFGNMPEQK GVIRAEHGPT CMVLHPLAGS PSKTKLTWLL SIDLKGWLPK SIINQVLSQT QVDFANHLRK RLESHPASEA RC
靶标信息
Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: cholesterol trafficker; Luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP
基因别名: AV363654; D8Ertd419e; STAR; STARD1
UniProt ID: (Human) P49675, (Mouse) P51557, (Rat) P97826
Entrez Gene ID: (Human) 6770, (Mouse) 20845, (Rat) 25557
steroid biosynthetic process
bile acid biosynthetic process
estrogen biosynthetic process
transport
lipid transport
glucocorticoid metabolic process
positive regulation of gene expression
cellular response to interferon-alpha
negative regulation of neuron apoptotic process
cellular lipid metabolic process
regulation of neuronal synaptic plasticity
positive regulation of neurogenesis
regulation of steroid biosynthetic process
organic acid metabolic process
progesterone biosynthetic process
brain development
response to nutrient
circadian rhythm
cholesterol metabolic process
male gonad development
response to herbicide
response to toxic substance
response to organic substance
response to ionizing radiation
response to lead ion
response to organic cyclic compound
response to activity
diterpenoid metabolic process
response to insecticide
insecticide metabolic process
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
phthalate metabolic process
response to nutrient levels
intracellular cholesterol transport
cellular response to insulin stimulus
response to gonadotropin
response to nicotine
response to drug
response to hydrogen peroxide
circadian sleep/wake cycle, REM sleep
response to peptide hormone
response to estrogen
response to leptin
cellular response to fibroblast growth factor stimulus
response to ethanol
response to antibiotic
response to steroid hormone
response to corticosterone
response to fungicide
testosterone biosynthetic process
cellular response to lipopolysaccharide
cellular response to antibiotic
cellular response to metal ion
cellular response to cadmium ion
cellular response to alkaloid
cellular response to cAMP
cellular response to glucose stimulus
cellular response to interferon-gamma
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to growth hormone stimulus
cellular response to organic cyclic compound
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
cellular response to epinephrine stimulus
C21-steroid hormone biosynthetic process
positive regulation of bile acid biosynthetic process
