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It is not recommended to aliquot this antibody.
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC59816; signal transducer and activator of transcription 2; STAT; STAT 2; STAT-2
基因别名: 1600010G07Rik; AW496480
Entrez Gene ID: (Mouse) 20847