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Invitrogen
STAT3 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
PA5-86074
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 680-720 of Human Stat3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2802874
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, and DNA binding activity. In humans, the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms of STAT3 have been described. Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acute phase response factor; Acute-phase response factor; DNA-binding protein APRF; FLJ20882; MGC16063; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT
基因别名: 1110034C02Rik; ADMIO; ADMIO1; APRF; AW109958; HIES; STAT3
UniProt ID: (Human) P40763, (Rat) P52631, (Mouse) P42227
Entrez Gene ID: (Human) 6774, (Rat) 25125, (Mouse) 20848
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
protein phosphatase binding
chromatin DNA binding
CCR5 chemokine receptor binding
glucocorticoid receptor binding
identical protein binding
transcription regulatory region DNA binding
protein dimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
temperature homeostasis
eye photoreceptor cell differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
protein import into nucleus
movement of cell or subcellular component
acute-phase response
signal transduction
JAK-STAT cascade
nervous system development
aging
cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of hydrogen peroxide biosynthetic process
viral process
phosphorylation
cytokine-mediated signaling pathway
sexual reproduction
intracellular receptor signaling pathway
response to estradiol
cellular response to hormone stimulus
leptin-mediated signaling pathway
somatic stem cell population maintenance
miRNA mediated inhibition of translation
regulation of multicellular organism growth
response to drug
positive regulation of tyrosine phosphorylation of Stat3 protein
glucose homeostasis
eating behavior
negative regulation of apoptotic process
cellular response to leptin stimulus
response to leptin
response to ethanol
positive regulation of Notch signaling pathway
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of mitochondrial membrane permeability
astrocyte differentiation
regulation of cell cycle
radial glial cell differentiation
regulation of feeding behavior
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-6-mediated signaling pathway
cellular response to organic cyclic compound
energy homeostasis
negative regulation of neuron death
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of metalloendopeptidase activity
positive regulation of gene silencing by miRNA
positive regulation of ATP biosynthetic process
negative regulation of neuron migration
response to organic substance
response to organic cyclic compound
stem cell population maintenance
response to cytokine
response to peptide hormone
negative regulation of cell death
transcription, DNA-templated
