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STAT5 Polyclonal Antibody

查看其他12个STAT5 alpha/beta抗体

抗体检测数据 (3)

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STAT5 Antibody (BS-1142R) in IHC (P)

Paraformaldehyde-fixed, paraffin embedded Human endometrial cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with STAT5 Polyclonal Antibody, Unconjugated (bs-1142R) at 1:200 overnight at 4°C, DAB staining.

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Paraformaldehyde-fixed, paraffin embedded Human endometrial cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with STAT5 Polyclonal Antibody, Unconjugated (bs-1142R) at 1:200 overnight at 4°C, DAB staining.

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded human lung carcinoma with labeled Anti-Cytomegalovirus pp65 Polyclonal Antibody, Unconjugated (bs-0271R) at 1:200, followed by conjugation to the secondary antibody and DAB staining.

STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded mouse lymph node tissue labeled with Anti-STAT5 Polyclonal Antibody, Unconjugated (bs-1142R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

产品信息

BS-1142R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

免疫组化（石蜡） (IHC (P))

1:200

-

免疫组化（冰冻） (IHC (F))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

-

产品规格

种属反应

Bovine, Human, Mouse, Pig, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human STAT5.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; mammary gland factor; transcription factor; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; signal transducer and activator of transcription factor 5A; STA5B; STAT; STAT5A, Mammary Gland Factor; transcription factor STAT5B

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基因别名: AA959963; MGF; Mpf; STAT5; STAT5A; STAT5A/MGF; STAT5B; STATA5

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UniProt ID: (Human) P42229, (Pig) Q9TUZ1, (Bovine) Q95115, (Bovine) Q9TUM3, (Human) P51692, (Pig) Q9TUZ0, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) Q541Q5

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Entrez Gene ID: (Human) 6776, (Pig) 397550, (Bovine) 282375, (Bovine) 282376, (Human) 6777, (Pig) 397340, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851

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DNA binding transcription factor activity, sequence-specific DNA binding protein tyrosine kinase activity signal transducer activity protein binding chromatin binding protein dimerization activity RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding protein phosphatase binding glucocorticoid receptor binding double-stranded DNA binding sequence-specific DNA binding DNA-binding transcription factor

参与通路

allantoin metabolic process positive regulation of endothelial cell proliferation citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated regulation of transcription from RNA polymerase II promoter isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process JAK-STAT cascade lactation peptidyl-tyrosine phosphorylation taurine metabolic process prolactin signaling pathway regulation of multicellular organism growth positive regulation of blood vessel endothelial cell migration creatinine metabolic process JAK-STAT cascade involved in growth hormone signaling pathway luteinization natural killer cell differentiation female pregnancy positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway lipid storage regulation of cell adhesion regulation of epithelial cell differentiation mammary gland development positive regulation of interleukin-2 production positive regulation of multicellular organism growth positive regulation of activated T cell proliferation T cell homeostasis negative regulation of apoptotic process positive regulation of B cell differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter development of secondary female sexual characteristics positive regulation of inflammatory response progesterone metabolic process positive regulation of erythrocyte differentiation development of secondary male sexual characteristics cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus response to hypoxia liver development transcription from RNA polymerase II promoter acute-phase response response to estradiol response to lipopolysaccharide positive regulation of natural killer cell proliferation positive regulation of natural killer cell differentiation cellular response to hormone stimulus T cell differentiation in thymus positive regulation of interleukin-2 biosynthetic process response to ethanol positive regulation of gamma-delta T cell differentiation positive regulation of natural killer cell mediated cytotoxicity Peyer's patch development positive regulation of smooth muscle cell proliferation positive regulation of cellular component movement response to interleukin-2 response to interleukin-4 response to interleukin-15 mast cell migration regulation of transcription, DNA-templated signal transduction response to nutrient levels negative regulation of mast cell apoptotic process response to peptide hormone positive regulation of lymphocyte differentiation multicellular organismal reproductive process mammary gland involution positive regulation of mast cell differentiation prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus sex differentiation