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STAT5 Antibody (606-300) in IHC (P)
Immunohistochemistry: Human colon carcinoma (FFPE) stained with Mouse anti- STAT5 (Cat# 606-300) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
产品信息
606-300
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
205
抗原
A synthetic peptide STAT5
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Positive control: Brain tissue
Cellular location: Cytoplasm, nucleus.
靶标信息
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B
基因别名: MGF; STAT5; STAT5A; STAT5B
UniProt ID: (Human) P42229, (Human) P51692
Entrez Gene ID: (Human) 6776, (Human) 6777
DNA binding
transcription factor activity, sequence-specific DNA binding
protein tyrosine kinase activity
signal transducer activity
protein binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein phosphatase binding
glucocorticoid receptor binding
protein dimerization activity
DNA-binding transcription factor
allantoin metabolic process
positive regulation of endothelial cell proliferation
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
JAK-STAT cascade
lactation
peptidyl-tyrosine phosphorylation
taurine metabolic process
prolactin signaling pathway
regulation of multicellular organism growth
positive regulation of blood vessel endothelial cell migration
creatinine metabolic process
JAK-STAT cascade involved in growth hormone signaling pathway
luteinization
response to hypoxia
natural killer cell differentiation
liver development
transcription from RNA polymerase II promoter
acute-phase response
female pregnancy
regulation of steroid metabolic process
lipid storage
regulation of epithelial cell differentiation
response to estradiol
response to lipopolysaccharide
positive regulation of natural killer cell proliferation
positive regulation of natural killer cell differentiation
cellular response to hormone stimulus
T cell differentiation in thymus
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
progesterone metabolic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of interleukin-2 biosynthetic process
response to ethanol
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of erythrocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of natural killer cell mediated cytotoxicity
development of secondary female sexual characteristics
development of secondary male sexual characteristics
Peyer's patch development
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of cellular component movement
response to interleukin-2
response to interleukin-4
response to interleukin-15
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
mast cell migration
