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产品信息
PA5-142863
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-KYYTPVLAKAVD.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933506
产品详细信息
Additional Information: This antibody is not expected to cross-react with STAT5B.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
靶标信息
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
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生物信息学
蛋白别名: Signal transducer and activator of transcription 5A; STAT; STAT5B
基因别名: MGF; STAT5; STAT5A
UniProt ID: (Human) P42229
Entrez Gene ID: (Human) 6776
allantoin metabolic process
positive regulation of endothelial cell proliferation
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
JAK-STAT cascade
lactation
peptidyl-tyrosine phosphorylation
taurine metabolic process
prolactin signaling pathway
regulation of multicellular organism growth
positive regulation of blood vessel endothelial cell migration
creatinine metabolic process
JAK-STAT cascade involved in growth hormone signaling pathway
