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产品信息
PA5-110442
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 366-465 of human STK38 (NP_0092021)
偶联物
形式
Liquid
浓度
1.29 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855853
产品详细信息
Immunogen sequence: ILKPTVATSN HPETDYKN
靶标信息
STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ndr Ser/Thr kinase-like protein; NDR1 protein kinase; Nuclear Dbf2-related kinase 1; Serine/threonine-protein kinase 38; stk38
基因别名: 5830476G13Rik; 9530097A09Rik; AA617404; NDR; NDR1; STK38
UniProt ID: (Human) Q15208, (Mouse) Q91VJ4
Entrez Gene ID: (Human) 11329, (Mouse) 106504
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
mitogen-activated protein kinase kinase kinase binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
