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产品信息
H00011329-M02
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3A5
抗原
STK38 (AAH12085, 365 a.a. approximately 465 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: EHRIGAPGVE EIKSNSFFEG VDWEHIRERP AAISIEIKSI DDTSNFDEFP ESDILKPTVA TSNHPETDYK NKDWVFINYT YKRFEGLTAR GAIPSYMKAA K
靶标信息
STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ndr Ser/Thr kinase-like protein; NDR1 protein kinase; Nuclear Dbf2-related kinase 1; Serine/threonine-protein kinase 38; stk38
基因别名: 5830476G13Rik; 9530097A09Rik; AA617404; NDR; NDR1; STK38
UniProt ID: (Human) Q15208, (Mouse) Q91VJ4
Entrez Gene ID: (Human) 11329, (Mouse) 106504, (Rat) 361813
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
mitogen-activated protein kinase kinase kinase binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
molecular_function
non-receptor serine/threonine protein kinase
