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产品信息
7341-MSM1-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
SM1, 495
抗原
Recombinant human SUMO1 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
This antibody is predicted to have broad species reactivity.
靶标信息
SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment, via an isopeptide bond, to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved, for instance, in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. SUMO1 may also regulate a network of genes involved in palate development. Mutations in the gene can result in non-syndromic orofacial cleft 10.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CG4494-PA; GAP modifying protein 1; GAP-modifying protein 1; GMP1; LD07775p; OTTHUMP00000202403; OTTHUMP00000202404; OTTHUMP00000202405; OTTHUMP00000202406; OTTHUMP00000202409; OTTHUMP00000202410; Sentrin; Sentrin-1; Small ubiquitin-related modifier 1; small ubiquitin-related modifier-1; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; Smt3C; SUMO-1; Ubiquitin-homology domain protein PIC1; ubiquitin-like 1 (sentrin); Ubiquitin-like protein SMT3C; Ubiquitin-like protein UBL1
基因别名: DAP1; GMP1; OFC10; OK/SW-cl.43; PIC1; SENP2; SMT3; SMT3C; SMT3H3; SUMO1; UBL1
UniProt ID: (Human) P63165, (Rat) Q5I0H3
Entrez Gene ID: (Human) 7341, (Rat) 301442
DNA repair
double-strand break repair via nonhomologous end joining
viral process
protein sumoylation
PML body organization
positive regulation of protein complex assembly
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of action potential
negative regulation of transcription, DNA-templated
protein stabilization
palate development
regulation of interferon-gamma-mediated signaling pathway
global genome nucleotide-excision repair
regulation of cardiac muscle cell contraction
protein localization to nuclear pore
positive regulation of calcium-transporting ATPase activity
negative regulation of delayed rectifier potassium channel activity
regulation of transcription, DNA-templated
regulation of protein stability
regulation of calcium ion transmembrane transport
