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This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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蛋白别名: HSMT3; sentrin 2; Sentrin-2; Small ubiquitin-related modifier 2; Small ubiquitin-related modifier 3; SMT3 homolog 1; SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 2; SMT3 suppressor of mif two 3 homolog 3; Smt3A; Smt3B; SMT3C; SMT3H3; SUMO-2; SUMO-3; Ubiquitin-like protein SMT3A; Ubiquitin-like protein SMT3B; UBL1
基因别名: HSMT3; SMT3A; SMT3B; SMT3H1; SMT3H2; SUMO-3; SUMO2; SUMO3
UniProt ID: (Human) P61956, (Human) P55854
Entrez Gene ID: (Human) 6613, (Human) 6612