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SYK Antibody (A300-559A) in WB
Detection of human SYK by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Ramos cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-SYK antibody A300-559A (lot A300-559A-2) used for IP at 6 µg per reaction. SYK was also immunoprecipitated by a previous lot of this antibody (lot A300-559A-1) and rabbit anti-SYK antibody A300-558A For blotting immunoprecipitated SYK, A300-559A was used at 1 µg/ml. Detection: Chemilu... View More
产品信息
A300-559A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residues 350 and 400 of Human Spleen Tyrosine Kinase.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat and Pig
靶标信息
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72-Syk; SP1; Spleen tyrosine kinase; syk signaling; tyrosine-kinase syk; Tyrosine-protein kinase SYK
基因别名: p72-Syk; SYK
UniProt ID: (Human) P43405
Entrez Gene ID: (Human) 6850
angiogenesis
lymph vessel development
positive regulation of receptor internalization
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
macrophage activation involved in immune response
neutrophil activation involved in immune response
leukocyte activation involved in immune response
serotonin secretion by platelet
protein phosphorylation
inflammatory response
leukocyte cell-cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
activation of JUN kinase activity
cell proliferation
organ morphogenesis
regulation of platelet activation
regulation of tumor necrosis factor-mediated signaling pathway
viral process
peptidyl-serine phosphorylation
leukotriene biosynthetic process
platelet activation
neutrophil chemotaxis
receptor internalization
positive regulation of type I interferon production
regulation of superoxide anion generation
positive regulation of cell adhesion mediated by integrin
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
defense response to bacterium
transcription factor import into nucleus
positive regulation of mast cell degranulation
regulation of neutrophil degranulation
beta selection
innate immune response
positive regulation of interleukin-3 biosynthetic process
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of bone resorption
positive regulation of alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
blood vessel morphogenesis
positive regulation of cytokine secretion
positive regulation of peptidyl-tyrosine phosphorylation
regulation of phagocytosis
positive regulation of calcium-mediated signaling
B cell receptor signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
regulation of ERK1 and ERK2 cascade
cellular response to molecule of fungal origin
cellular response to low-density lipoprotein particle stimulus
regulation of arachidonic acid secretion
regulation of platelet aggregation
