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Immunogen sequence: HVTPKTPPPM APKTPPPMTP KTPPPVAPKP PSRGLLDGLV NGAASSAGIP EPPRLQGRGG ELFAKRQSRA DRYVVEGTPG PGLGPRPRSP SPTPSLPPSW K; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, cytoskeleton
SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Synaptopodin 2-like protein
基因别名: 1110054M18Rik; Chap; Synpo2l
UniProt ID: (Mouse) Q8BWB1
Entrez Gene ID: (Mouse) 68760