Proteintech

Sam68 Polyclonal Antibody

Sam68 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Sam68 Antibody (10222-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 10222-1-AP (KHDRBS1 antibody) at dilution of 1:50 (under 10x lens).

Sam68 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Sam68 Antibody in Immunoprecipitation (IP)

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产品信息

10222-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:500

免疫细胞化学 (ICC/IF)

1:50-1:500

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells

免疫沉淀 (IP)

0.5-4.0 µg

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RNA免疫共沉淀 (RIP)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Sam68 Fusion Protein Ag0235 (200-442 aa encoded by BC000717)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This is a rabbit polyclonal antibody raised against residues near the N-terminus of human KHDRBS1.

Immunogen sequence: KGSMRDKAK EEELRKGGDP KYAHLNMDLH VFIEVFGPPC EAYALMAHAM EEVKKFLVPD MMDDICQEQF LELSYLNGVP EPSRGRGVPV RGRGAAPPPP PVPRGRGVGP PRGALVRGTP VRGAITRGAT VTRGVPPPPT VRGAPAPRAR TAGIQRIPLP PPPAPETYEE YGYDDTYAEQ SYEGYEGYYS QSQGDSEYYD YGHGEVQDSY EAYGQDDWNG TRPSLKAPPA RPVKGAYREH PYGR (200-442 aa encoded by B C000717)

靶标信息

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

HnRNPR strongly represses splicing of a critical exon associated with spinal muscular atrophy through binding to an exonic AU-rich element.

Journal of medical genetics

Jiang T,Qu R,Liu X,Hou Y,Wang L,Hua Y

Wed Nov 01 00:00:00 EDT 2023

Shortening of the KHDRBS1 3'UTR by alternative cleavage and polyadenylation alters miRNA-mediated regulation and promotes gastric cancer progression.

American journal of translational research

Yu X,Kang W,Zhang J,Chen C,Liu Y

Wed Oct 19 00:00:00 EDT 2022

Shortening of the KHDRBS1 3'UTR by alternative cleavage and polyadenylation alters miRNA-mediated regulation and promotes gastric cancer progression.

American journal of translational research

Yu X,Kang W,Zhang J,Chen C,Liu Y

Wed Oct 19 00:00:00 EDT 2022

SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing.

Theranostics

Zhu S,Chen W,Wang J,Qi L,Pan H,Feng Z,Tian D

Fri Jul 23 00:00:00 EDT 2021

LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.

Molecular therapy. Nucleic acids

Feng J,Ren X,Fu H,Li D,Chen X,Zu X,Liu Q,Wu M

Fri Dec 03 00:00:00 EST 2021

LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.

Molecular therapy. Nucleic acids

Feng J,Ren X,Fu H,Li D,Chen X,Zu X,Liu Q,Wu M

Fri Dec 03 00:00:00 EST 2021

LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.

Molecular therapy. Nucleic acids

Feng J,Ren X,Fu H,Li D,Chen X,Zu X,Liu Q,Wu M

Fri Dec 03 00:00:00 EST 2021

Cold-induced RNA-binding protein (CIRBP) regulates the expression of Src-associated during mitosis of 68 kDa (Sam68) and extracellular signal-regulated kinases (ERK) during heat stress-induced testicular injury.

Reproduction, fertility, and development

Xu C,Ke D,Zou L,Li N,Wang Y,Fan X,Zhu C,Xia W

Tue Dec 01 00:00:00 EST 2020

Regulatory T cells delay disease progression in Alzheimer-like pathology.

Brain : a journal of neurology

Dansokho C,Ait Ahmed D,Aid S,Toly-Ndour C,Chaigneau T,Calle V,Cagnard N,Holzenberger M,Piaggio E,Aucouturier P,Dorothée G

Fri Apr 01 00:00:00 EDT 2016

Regulatory T cells delay disease progression in Alzheimer-like pathology.

Brain : a journal of neurology

Dansokho C,Ait Ahmed D,Aid S,Toly-Ndour C,Chaigneau T,Calle V,Cagnard N,Holzenberger M,Piaggio E,Aucouturier P,Dorothée G

Fri Apr 01 00:00:00 EDT 2016

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica

Neumann M,Valori CF,Ansorge O,Kretzschmar HA,Munoz DG,Kusaka H,Yokota O,Ishihara K,Ang LC,Bilbao JM,Mackenzie IR

Thu Nov 01 00:00:00 EDT 2012

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica

Neumann M,Valori CF,Ansorge O,Kretzschmar HA,Munoz DG,Kusaka H,Yokota O,Ishihara K,Ang LC,Bilbao JM,Mackenzie IR

Thu Nov 01 00:00:00 EDT 2012

生物信息学

蛋白别名: FLJ34027; GAP-associated tyrosine phosphoprotein p62; GAP-associated tyrosine phosphoprotein p62 (Sam68); KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KHDRBS1; khdrbs1 {ECO:0000312|RGD:621459}; p21 Ras GTPase-activating protein-associated p62; p68; Sam68; src associated in mitosis, 68 kDa; Src-associated in mitosis 68 kDa protein

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基因别名: KHDRBS1; P62; p68; SAM68

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UniProt ID: (Human) Q07666, (Mouse) Q60749, (Rat) Q91V33

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Entrez Gene ID: (Human) 10657, (Mouse) 20218, (Rat) 117268

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功能