Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
10761-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Secretogranin V Fusion Protein Ag1107 (1-212 aa encoded by BC005349)
偶联物
Unconjugated
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MVSRMVSTM LSGLLFWLAS GWTPAFAYSP RTPDRVSEAD IQRLLHGVME QLGIARPRVE YPAHQAMNLV GPQSIEGGAH EGLQHLGPFG NIPNIVAELT GDNIPKDFSE DQGYPDPPNP CPVGKTADDG CLENTPDTAE FSREFQLHQH LSDPEHDYPG LGKWNKKLLY EKMKGGERRK RRSVNPYLQG QRLDNVVAKK SVPHFSDEDK DPE (1-212 aa encoded by BC005349)
靶标信息
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Neuroendocrine protein 7B2; P SGNE1; Pituitary polypeptide; prohormone convertase chaperone; Secretogranin V; secretogranin V (7B2 protein); Secretogranin-5; Secretory granule endocrine protein I; secretory granule neuroendocrine protein 1; secretory granule neuroendocrine protein 1, 7B2 protein; Secretory granule neuroendocrine, protein 1 (7B2 protein); secretory granule, neuroendocrine protein 1 (7B2 protein)
基因别名: 7B2; AI325031; P7B2; SCG5; Sgne-1; SGNE1; SgV
UniProt ID: (Human) P05408, (Mouse) P12961, (Rat) P27682
Entrez Gene ID: (Human) 6447, (Mouse) 20394, (Rat) 25719
