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Septin 2 Antibody (MA5-38165) in WB
Western blot analysis of Septin 2 in extracts of various cell lines. Samples were incubated with Septin 2 Monoclonal antibody (Product # MA5-38165) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
MA5-38165
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1810
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 202-298 of human Septin 2 (Q15019)
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898082
产品详细信息
Positive Samples: PC-3, SH-SY5Y, Mouse testis, Mouse brain, Rat brain
Immunogen sequence: EIEEHNIKIY HLPDAESDED EDFKEQTRLL KASIPFSVVG SNQLIEAKGK KVRGRLYPWG VVEVENPEHN DFLKLRTMLI THMQDLQEVT QDLHYEN
靶标信息
Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-Sep; NEDD-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Septin-2; Vascular endothelial cell specific protein 11
基因别名: AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD-5; NEDD5; Pnutl3; SEPT2; SEPTIN2; Vesp11
UniProt ID: (Human) Q15019, (Mouse) P42208, (Rat) Q91Y81
Entrez Gene ID: (Human) 4735, (Mouse) 18000, (Rat) 117515
regulation of L-glutamate transport
mitotic nuclear division
smoothened signaling pathway
neuron projection development
regulation of protein localization
cilium assembly
regulation of catalytic activity
cell division
cell-cell adhesion
cytokinesis
cell cycle
protein polymerization
metabolic process
