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Sodium Channel Pan Antibody (PA5-77723) in IHC
Immunohistochemistry analysis of Sodium Channel Pan in rat cerebellum. A) Samples were probed with Sodium Channel Pan polyclonal antibody (Product # PA5-77723) and incubated with parvalbumin (green). B) Brain section stained image. C) Merged image of Panels A and B.
产品信息
PA5-77723
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat Nav 1.1
偶联物
Unconjugated
形式
Lyophilized
浓度
0.95 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2736645
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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