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Invitrogen
Sortilin Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Sortilin Antibody (PA5-19481) in WB
Western blot was performed using Sortilin Polyclonal Antibody (Product # PA5-19481) and a 110kDa band corresponding to SORT1 was observed across all cell lines and tissues tested except Mouse and Rat liver. Whole cell extracts (30 µg lysate) of SK-BR-3 (Lane 1), MDA-MB-231 (Lane 2), BeWo (Lane 3), HeLa (Lane 4), Mouse brain (Lane 5), Rat brain (Lane 6), Mouse liver (Lane 7), Rat liver (Lane 8), and Mouse colon (Lane 9)were electrophoresed using NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX). Resolved proteins were then transferred onto ... View More
产品信息
PA5-19481
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Human Sortilin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10986596
产品详细信息
PA5-19481 targets Sortilin in flow cytometry, immunoprecipitation, immunocytochemistry, immunofluorescence, immunohistochemistry (frozen), and Western blot applications and shows reactivity with Human, mouse, Cow, and Rat samples.
The PA5-19481 immunogen is synthetic peptide conjugated to KLH derived from within residues 800 to the C-terminus of Human Sortilin.
PA5-19481 detects Sortilin which has a predicted molecular weight of approximately ~100 kDa.
靶标信息
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 100 kDa NT receptor; Glycoprotein 110; Glycoprotein 95; Gp110; Gp95; mNTR3; Neurotensin receptor 3; NT3; NTR3; Sortilin
基因别名: 2900053A11Rik; AI852375; Gp95; LDLCQ6; NT3; NTR3; Nts3; Ntsr3; SORT1
UniProt ID: (Human) Q99523, (Mouse) Q6PHU5, (Rat) O54861
Entrez Gene ID: (Human) 6272, (Mouse) 20661, (Rat) 83576
ossification
Golgi to endosome transport
endocytosis
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
multicellular organism development
endosome to lysosome transport
extrinsic apoptotic signaling pathway via death domain receptors
regulation of gene expression
myotube differentiation
vesicle organization
endosome transport via multivesicular body sorting pathway
response to insulin
nerve growth factor signaling pathway
negative regulation of fat cell differentiation
glucose import
neurotrophin TRK receptor signaling pathway
plasma membrane to endosome transport
negative regulation of lipoprotein lipase activity
positive regulation of epithelial cell apoptotic process
transport
cell differentiation
intracellular protein transport
